{"id":4546,"date":"2019-02-11T08:41:29","date_gmt":"2019-02-11T08:41:29","guid":{"rendered":"http:\/\/www.thinkkidneys.nhs.uk\/aki\/?p=4546"},"modified":"2019-02-11T08:41:35","modified_gmt":"2019-02-11T08:41:35","slug":"aki-bundles-and-measuring-aki-outcomes-what-should-we-be-focusing-on","status":"publish","type":"post","link":"https:\/\/www.thinkkidneys.nhs.uk\/aki\/blog\/aki-bundles-and-measuring-aki-outcomes-what-should-we-be-focusing-on\/","title":{"rendered":"AKI bundles and measuring AKI outcomes\u2026.  What should we be focusing on?"},"content":{"rendered":"\n<p>At my hospital I have been collecting inpatient mortality\ndata for non-elective admissions, for over two years now and I\u2019m able to\ncompare mortality rates for patients with and without AKI.&nbsp; I suspect a similar aim of the UK Renal\nRegistry and Think Kidney\u2019s AKI programme is to provide similar data for\nhospitals and regions.&nbsp; One aspect that I\nhave found interesting is that in the whole of 2017, the average (incl.\nAKI 1-3 patients) AKI inpatient crude mortality rate for non-elective\nadmissions ran at around 16% vs. 1.4% for similar patients who did not have or\ndevelop AKI.&nbsp; In December 2017, the\nmortality rate peaked from 16.5% in October 2017 to 28.8%!&nbsp; <\/p>\n\n\n\n<p>This was a huge spike, but not altogether unexpected in\nseeing first-hand, how busy the NHS was last Winter and the severity of illness\nthat patients were presenting with.&nbsp; One\nof my first blogs covered this topic in some detail.&nbsp; This mortality spike seen in December 2017\npersisted way beyond the expected \u2018winter-pressures\u2019 with mortality not falling\nbelow 22% until May 2018 when it dipped down to early 2017 levels at 15.3%.&nbsp; Patients without AKI during this time had a\nmortality consistently around 1.6% with no such fluctuation seen.&nbsp; The \u2018normalised\u2019 AKI mortality of 15.3%\nremained throughout the summer, but unfortunately spiked again at the end of\nSeptember 2018 to 21.6% vs. 1.4% without AKI and remained around 20% into the\nWinter months.&nbsp; <\/p>\n\n\n\n<p>The reason for highlighting this average mortality\nfluctuation, is that AKI seems to have huge variation in its crude mortality\ntrends, which I suspect is not limited to just my hospital but UK-wide. &nbsp;&nbsp;This makes study design extremely difficult\nas showing any effect (hopefully beneficial) from interventions like AKI\nbundles is a real problem, particularly when AKI mortality can fall 10% at the\ndrop of a hat! <\/p>\n\n\n\n<p>However, all is not lost!&nbsp;\nOver the last year, there has been a number of AKI and Fluid management\ninterventions made by my hospital including the introduction of an\nelectronic-observation system (Vital-Pac<sup>TM<\/sup>), with ward online fluid\nmanagement documentation and integrated AKI e-alerts to complement the Trust\nAKI bundle.&nbsp; This and daily automated new\nAKI patient lists, for teams such as outreach and pharmacy to use, allow almost\nall new AKI cases to be seen in addition to medical team review and acted upon\nwith bundle interventions started within 24h of AKI e-alert. &nbsp;&nbsp;It is difficult to confidently show a\nsignificant reduction in AKI mortality outcomes from crude mortality rates\nalone.&nbsp; However, if one is to look at the\n<strong>Hospital Standardised Mortality Ratio\n(HSMR)<\/strong> for AKI, our hospital has shown a significant reduction in AKI\nmortality over the last year (September 2017 to October 2018) since the\nintroduction of AKI interventions, with HSMR falling well below\nUK-average.&nbsp;&nbsp; <\/p>\n\n\n\n<p>The HSMR scoring system works by taking a hospital\u2019s crude\nmortality rate and adjusting it for a number of factors including population\nsize, age and poverty.&nbsp; From this it is\npossible to calculate two scores, the expected mortality rate for any given\nhospital and actual observed mortality rate.&nbsp;\nIt is the difference between expected and observed mortality that is\nimportant when considering HSMR.&nbsp; HSMR\nfor a given condition such as AKI, allows mortality rates between different\nhospitals and regions to be statistically compared and is used frequently as a\nmortality comparator between Trusts (see Dr Foster Intelligence). &nbsp;&nbsp;&nbsp;When comparing similar sized hospitals\n(regional peers) our AKI mortality is comparable and one of the better\nperformers, which is really reassuring that what we are doing as a Trust is\nhaving a positive impact on patient mortality.&nbsp;\nI believe that AKI e-alerting and the Trust response to AKI presence\nthrough the AKI bundle and staff intervention is key and has really made this\ndifference possible and something my Trust should be proud of!&nbsp;&nbsp;&nbsp; <\/p>\n\n\n\n<p>It is clear from this, that crude hospital AKI inpatient\nmortality is probably far too insensitive to be a useful improvement measure.&nbsp; It is influenced by too many patient and\nhospital factors!&nbsp; However, standardised\nHSMR is potentially a more robust measure of AKI mortality and may be something\nfor Trust\u2019s to look at more closely when trying to benchmark improvement.&nbsp; <\/p>\n\n\n\n<p>For other AKI outcomes, I believe that some refocus is\nneeded.&nbsp; For example, when looking at\nnon-elective inpatient mortality in my Trust.&nbsp;\nThis group of patients due to their emergency presentation are at least 4x\nat risk of AKI versus elective admissions, they are more likely to be medical\npatients with a large majority being over the age of 65years.&nbsp; Consistently 50-60% of these patients develop\nAKI in the community and present with it on hospital admission.&nbsp; They are an extremely heterogenous group with\nmany different causes of their AKI, with sepsis and hypovolaemia being most\noften to blame.<\/p>\n\n\n\n<p><strong>So how do we refocus\nour outcome aims?&nbsp; <\/strong><\/p>\n\n\n\n<p>Patients who develop AKI in the community (e.g.\nCommunity-Acquired AKI) before hospital admission are in my view a different\ncohort of patients to those who did not have AKI on admission but then developed\nit whilst in hospital (e.g. Hospital-Acquired AKI).&nbsp; Such groups could then be subdivided further\ninto non-elective and elective admissions.&nbsp;\nAll groups are important to tackle, but it is possible that those who\ndevelop AKI in hospital may have been more preventable than those who developed\nit in the community or potentially have more learning points to consider and\nintervene on.&nbsp; Who knows, this is just a\nhunch! It is important to investigate and consider whether this is indeed true,\nas it may involve different preventative strategies and approach for the community\nversus the hospital.&nbsp; One size does not\nalways fit all!&nbsp; Many Critical Care\nstudies in the past have failed when a strategy has been applied to the whole\ncritical care cohort rather than focusing down on specific subgroups of\npatients, where certain interventions are of benefit, making a true real\ndifference! &nbsp;&nbsp;If NCEPOD is to be believed, only 30% of all\nAKI cases in hospital were deemed preventable, with the vast majority of\npatients developing AKI due to severity of their disease process regardless of\nwhat preventative measures were employed.&nbsp;\nHowever, hospital AKI bundles may be more effective in those who have\nhospital-acquired rather than community-acquired AKI with such interventions\nimproving time taken for AKI resolution and peak severity.&nbsp; We may not be able to prevent AKI development\nin the majority, but our interventions could make a difference in bringing\nabout prompt resolution!&nbsp; Ultimately, it is\nhoped that such subgroup improvements could influence favourably overall\nmortality and length of stay.&nbsp; <\/p>\n\n\n\n<p>There is still a lot of work to do in the face of increasing\nscrutiny from hospital management of AKI interventions and effectiveness versus\nthe cost of providing such resources.&nbsp; We\nconstantly need to justify why such initiatives are needed!&nbsp; AKI HSMR and focusing on AKI subgroup\noutcomes may indeed add to the growing evidence for AKI bundle use, providing\nmuch needed proof, that when employed with AKI e-alerts and other\ninterventions, AKI bundles do really make a difference to our patient\u2019s lives\nand hospital outcomes!&nbsp; <\/p>\n\n\n\n<p>&nbsp;&nbsp;\niSpyAKI<\/p>\n\n\n\n<figure class=\"wp-block-image\"><img loading=\"lazy\" decoding=\"async\" width=\"97\" height=\"62\" src=\"http:\/\/www.thinkkidneys.nhs.uk\/aki\/wp-content\/uploads\/sites\/2\/2018\/02\/ISPYAKI-logo.png\" alt=\"\" class=\"wp-image-4217\"\/><\/figure>\n\n\n\n<p>References:<\/p>\n\n\n\n<p>1.&nbsp; Dr Foster\nIntelligence:&nbsp; <a href=\"https:\/\/www.drfoster.com\/service\/quality-and-outcomes-measurement\/#product-mortality-comparator\">https:\/\/www.drfoster.com\/service\/quality-and-outcomes-measurement\/#product-mortality-comparator<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>At my hospital I have been collecting inpatient mortality data for non-elective admissions, for over two years now and I\u2019m able to compare mortality rates for patients with and without AKI.&nbsp; I suspect a similar aim of the UK Renal Registry and Think Kidney\u2019s AKI programme is to provide similar data for hospitals and regions.&nbsp; One aspect that I have found interesting is that in the&#8230;<\/p>\n","protected":false},"author":106,"featured_media":4217,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_bbp_topic_count":0,"_bbp_reply_count":0,"_bbp_total_topic_count":0,"_bbp_total_reply_count":0,"_bbp_voice_count":0,"_bbp_anonymous_reply_count":0,"_bbp_topic_count_hidden":0,"_bbp_reply_count_hidden":0,"_bbp_forum_subforum_count":0,"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"enabled":false},"version":2}},"categories":[1],"tags":[],"class_list":["post-4546","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-blog"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v25.5 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>AKI bundles and measuring AKI outcomes\u2026. 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